Oleoylethanolamide (OEA)

CAS : 111-58-0
EINECS： 203-884-8
Molecular Weight: 325.53
Molecular Formula: C20H39NO2
Other Names: N-(2-Hydroxyethyl)-9-octadecenamide,9-octadecenamide,N-Oleoylethanolamine
Solubility: chloroform, ethanol, methanol, ethyl ether,,DMSO
Manufacturer: Cima
Package: 1kg/bag, 25kg/drum

Introduction
CimaSci promotes health and well-being through the discovery and development of nutraceutical ingredient which can be integrated into dietary splements, nutritional production and medicine.

Oleoylethanolamide (OEA) is an endocannabinoid analog thaupt belongs to a family of endogenous acylethanolamides. Increasing evidence suggest that OEA may act as an endogenous neuroprotective factor and participate in the control of reward-related behaviors. Also, it has been described as a peripherally acting agent that reduces food intake and body weight gain.

Function:
 Modulate food intake
 Modulate lipid and glucose metabolism
 Beneficial effect on analgesic
 Promote neurogenesis and neuroplasticity after focal cerebral ischemia

 Antidepressant

Oleoylethanolamide or OEA is a member of the naturally occurring family of fatty acids traceable in both animal and plant organisms. However, this supplement did not receive a universal recognition until it was discovered that a member of the same family known by the name of anadamide served as an endogenous ligand for cannabinoid receptors.

What is striking about OEA is that their percentage of occurrence is higher during the day when the body remain fully saturated with food and lower during nighttime when the body remain fully awake and constantly goes on feeding. Such discoveries prove that OEA is capable enough to affect both appetite and feeding behavior of an individual.

Other than its ability to suppress appetite, Oleoylethanolamide (OEA), it also encourages and provokes fatty acid catabolism, lower blood lipid levels and lower body weight gain. OEA is a lipid produced in the intestine, which minimizes the intake of essential food matters and rouses lipolysis through peroxisome proliferator. Results have proved that OEA is capable of reducing food consumption.

Oleoylethanolamide (OEA) is significantly an endogenous lipid that controls and normalizes both feeding patterns and body weight. It has usually been observed that the effects of OEA basically depend on the activation of vagal sensory afferent neurons. However, the mechanisms involved in exhilarating and stimulating these neurons are still vague and unclear.

In reality Oleoylethanolamide is a safe and cheap anti-obesity drug, which is utilized to assess the extent of catabolism in the gastro-intestinal tract. It helps to reduce fat without any detrimental side effects. This drug essentially spoils your desire to eat. Thus, a change in behavior results in low food intake and increased rate of metabolism, breaking down already existing fat content within your body thereby releasing required energy and vitality.

However, research shows that Oleoylethanolamide is a kind of lipid amide, which can be fast catabolized in the gastrointestinal tract thereby averting their use in form of anti-obesity compounds. Experiment proves that OEA is an endogenous regulator of food intake and an intraperitoneal injection of this particular compound can reduce the amount of food intake in just 24 hours time in case of starved rats.

Oleoylethanolamide (OEA) plays a significant role in protecting the human sperm cells from oxidation stress. It has been discovered that some N-acylethanonolamides like OEA possess antioxidative properties. It has generally been proved that about 2.5 nM oleoylethanolamide in vitro supplementation drastically reduces DNA strand breaks both in case of fertile and infertile subjects. In addition to this, Oleoylethanolamide also enhances kinematic parameters, such as curvilinear velocity and amplitude of lateral head displacement and hyperactivation both in the existence and nonexistence of oxidative stress.